1. NEWS FROM DPSG BOARD: DPSG BOOTH  AT the LISBON EASD MEEETING 2017

68 EASD attendees (62.8% women and 34.3% men) filled in the questionnaire exploring their experience in the field of Diabetes in pregnancy and their knowledge of DPSG mission. Forty five of the people who answered the questionnaire were European, sixteen Asian, two came from Australia, two from South America and four from Africa. The most represented age ranges were between 35-45 yrs (32,3%) and more than 55yrs (35.3%) 10.3% was less than 35yrs old and 22% between 45-55yrs. Most of the people who answered the questionnaire, (89.7 %), treat women with diabetes in pregnancy, 80.9% working in team and 51% in a dedicated ambulatory. About 88% od them treats  any type of diabetes in pregnancy whilst 13.2% Gestational diabetes, only. 73.5% screens pregnant women for gestational diabetes, in particular 45.6% by a universal screening and 29.4% with a risk factor strategydiagnostic critere were IADPSG criteria in 41.2% of cases, WHO in 27.9% and local criteria in 13.2%. The majority (64.7%) know DPSG and the large majority (94.1%) are interested in DPSG initiatives.

  1. NEWS FROM THE DPSG MEETING 2017 IN DENMARK

Best posters – John Stowers Research Award: 1. Tina Ravnsborg, 2. Wilson Kwong and 3. Delia Bogdanet. For abstracts, visit our website.

The Jorgen Pedersen Lecturer was held by Parri Wentzel

Abstracts from the DPSG meeting 2017

  • OP2 - Sandra Szlapinski and David J Hill: Fetal programming of gestational diabetes in mouse: A failure to adaptively increase B-cell mass during pregnancy

Comments by Marta Maria Viana Arribas: GDM is associated to a failure to adaptively increase of maternal b-cell mass, so the aim of this study was to develop a mouse model of GDM with the aim of identifying changes to adaptive b-cell mass, and its possible mechanism. They used the female offspring (F1), of mothers feed with low protein (LP) or control (C) diet during gestation and lactation, which were mated with control males, and subsequently fed with control diet during pregnancy. The authors were able to demonstrate how the low protein diet in the mother impaired in the F1 glucose tolerance and reduce the ability to adaptively increase b-cell mass, associating this fact with a decreased expansion of b-cell progenitors. This is a very interesting and promising model to further study mechanisms underlying b-cell failure programming by GDM.

  • OP19 - Fornes D, White V, Capobianco E, Jawerbaum A.: Changes in micro-RNAs that target PPARs and lipids accretion is sex-dependent in the fetal liver of rats with GDM

Comments by Marta Maria Viana Arribas: The authors had previously characterized a very interesting GDM diabetic rat model that is induced by developmental programming. In this model, diabetes is spontaneously induced during pregnancy when the offspring of mild diabetic rats are mated with control males. Using this model, they study the presence of liver alterations in the fetuses of GDM dams, as GDM impairs fetal metabolism and development, programing metabolic alterations in the offspring. They focus their attention in the status of liver lipid content, PPAR (nuclear receptor involved in development and metabolic regulation) levels and microRNAs that target PPARs in a sex-dependent manner. They demonstrate how the increased expression of PPAR correlated with a decreased expression in miR-130 in GDM male fetuses, and the increased in PPAR correlated with a decrease in miR-9 in GDM females, are related with changes in lipid accretion in GDM (increased in males and decreased in females) compare with controls. These sex-dependent alterations could lead to metabolic alterations and different adaptive response later in life.

  1. NEWS FROM WEBMASTER

As you may have experienced already, the layout of the website has changed. This is due to transfer of the website to a new host, where the previous layout was not compatible. During transfer almost everything was lost, and to recover the website is time consuming. The priority is to make the most important features to works. For access to PayPal for membership transfer you have to login before choosing “Members area”. All members contact information is awailable on the website, and it is now possible to write to a member directly from the website.

  1. EVENTS/AGENDA

The annual DPSG meeting will be held in Rome, September 27 to 30 2018. Call for abstract will be in March. For further information follow the update on the webiste: dpsghome.org.

 


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